Kelly’s combination syndrome occurs in patients belonging to the Eichner group C2 having acrylic dentures: complete in the jaw as well as mandibular bilateral distal‑extension partial dentures, or those who have only a complete upper denture. The characteristic clinical symptoms of this syndrome include the following: the loss of alveolar bone in the anterior part of the maxilla, the growth of maxillary tubers, the overgrowth of papillary mucous membrane in the central part of the hard palate, alveolar bone loss of the mandible, and the extrusion of lower teeth. All these factors make the proper prosthetic treatment difficult. Dentists try to overcome the difficulties associated with this syndrome through proper planning procedure, which in many cases requires cooperation with a specialist in dental surgery in any pre‑prosthetic treatment: correcting maxillary tuber/s, cutting excessively moving overgrown soft tissue, and implant restorations with an "overdenture" and so on. Despite the undoubted advantages of implantation procedures, a large number of patients require – for financial and medical reasons – treatment with conventional dentures. This article presents the case of a patient with Kelly’s syndrome and discusses various concepts regarding solving the problems associated with it.

Key words: combination syndrome, fibrous overgrowth of maxillary tuber, papillary overgrowth of palate, acrylic partial denture, overdenture.