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Influence of chlorhexidine and cetylpyridine on periodontal status in patients with type 1 diabetes

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Jakub Lipski, Anna Duda-Sobczak, Marzena Wyganowska-Świątkowska

2/2021/XLIX s. 90–94
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Fraza do cytowania: Lipski J., Duda-Sobczak A., Wyganowska-Świątkowska M. Influence of chlorhexidine and cetylpyridine on periodontal status in patients with type 1 diabetes. Dental Forum. 2021;XLIX(2):90–94. DOI:

Introduction. Periodontal inflammation may be one of the clinical symptoms of chronic inflammation in type 1 diabetes. Chronic hyperglycemia and oxidative stress have been shown to lead to an imbalance between opportunistic bacteria in the biofilm and the host, resulting in an infectious state and possible destruction of periodontal tissues. The gold standard in controlling the periopathogens in biofilm is mechanical debridement of the wound, assisted by rinsing the oral cavity with chemical agents. Aim. The aim of the study was to evaluate the effect of chlorhexidine digluconate and cetylpyridine chloride on periodontitis in patients with type 1 diabetes. Material and Methods. The study included 104 patients aged 28 (IQR 23–38) years with type 1 diabetes lasting 12 (8–18) years, glycosylated hemoglobin 8.21 (7.0–9.6)%. A clinical examination of the gum tissue was performed. The patients were examined twice - initially and after 14 days of using toothpaste with chlorhexidine and cetylpyridine. Results. There were significant changes in the clinical indicators of periodontal status before and after the application of the paste (API before 0.39 (0.25–0.67) vs API after 0.29 (0.21–0.43), p = 0.04; SBI before 0.09 (0.05–0.18) vs SBI after 0.02 (0–0.057), p = 0.003; GI before 0.95 (0.52–1) vs GI after 0.65 (0.26–1), p = 0.0007).

Key words: chlorhexidine digluconate, cetylpyridine chloride, periodontal condition, type 1 diabetes.

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