Biermer’s disease (pernicious anemia PA), is an autoimmune disease inducing vitamin B12 deficiency by malabsorption. The clinical presentation of Biermer’s disease (pernicious anemia), is often insidious because the onset is difficult to establish and progression is very slow. It rarely occurs before the age of 30, the mean age at which it is diagnosed being about 60. Patients may seek medical advice due to non-specific symptoms such as weakness, decreased mental concentration, and headaches. Biermer’s disease may be accompanied by other autoimmune diseases. Longstanding Helicobacter pylori infection probably plays a role in many patients with PA. In this case report a 22-year old woman with Biermer’s disease coexisting with Hashimoto thyroiditis and a Helicobacter pylori infection has been described. This case indicates the important role of dentists in the early diagnosis of this disease, especially in respect of later neurological complications.

Key words: Biermer’s disease, vitamin B12, anemia.