Medication safety is a constant concern for all health‑care practitioners. Due to the large number of patients who suffer from multiple diseases and have to use several medications simultaneously, many treatment errors may occur leading to unintended harm to patients every year. With the abundance of polypharmacy, medication record accuracy has become an ever‑increasing challenge for health‑care systems. To meet this accuracy, proper physician‑patient cooperation is pivotal issue determining both short- and long‑term therapy outcomes, including those of dental treatment. Safe and effective dental management of patients requires also precise medical reconciliation, i.e. knowledge of drugs used by patients It enables to identify high‑risk subjects and reduce the potential hazard in polypharmacy patients during dental treatment (drug‑drug interaction, adverse drug reactions, unwanted side effects).

Key words: pharmacotherapy, safety, dental treatment, polypragmasia.